Abstract 3292: Epsin promotes breast cancer progression and metastasis by controlling nf-κb activation

Abstract

Abstract Epsins are a family of endocytic clathrin adaptors. We have previously reported that epsin deficiency inhibits tumor growth by enhancing VEGF signaling in vascular endothelial cells. However, the pattern of tumor-intrinsic expression of epsin and its influence on cancer growth and metastasis is still unclear. Here, we demonstrate that epsin is upregulated in human cancers, including breast cancer, where its high expression correlates with poor relapse-free survival. Epsin promotes cell proliferation and invasion in vitro, and breast tumorigenesis and metastasis in vivo. Mechanistically, epsin interacts with and stabilizes TNFR1 signaling complex in breast cancer cells and enhances NF-κB signaling. Our findings suggest an important role of epsin in contributing to breast cancer progression and metastasis. Citation Format: Xiaofeng Cai, Hong Chen. Epsin promotes breast cancer progression and metastasis by controlling nf-κb activation. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3292. doi:10.1158/1538-7445.AM2014-3292