Abstract 3282: BMI and other factors in relation to overall survival of female breast cancer in China

Abstract

Abstract The aim of this study is to determine the relationship between body mass index(BMI) at diagnosis and various factors including the epidemiologic and clinical factors on survival of female breast cancers. We analysed the data of 653 patients in any stage from the Wuxi Breast Cancer Cohort. Cox Proportional Hazard regression models were conducted to compare the overall survival(OS) outcomes among BMI groups, and adjusted by covariates which yielded a >10% change in the hazard ratios(HRs) estimate, including age, stage, menopause status, physical activity in work. There were significant differences among BMI groups in age(P=0.000), WHR(P =0.000), physical activity in work(P =0.019),red meat intake(P =0.029), oil intake(P =0.000),tumor stage(P =0.021),menopause status(P =0.001). Overweight(OW,BMI=24 to 27.9kg/m2) and obesity(OB, BMI≥28kg/m2) showed better OS comparing with normal weight(NW, BMI=18.5 to 23.9kg/m2)(respectively, adjusted HRs=0.45, 95%CI=0.15 to 1.34, adjusted HRs=0.59,95%CI=0.21 to 1.69), meanwhile underweight(UW, BMI<18.5kg/m2) showed a poorer OS(adjusted HRs=4.65,95%CI=0.93 to 23.37). There was no significant relationship between the BMI and some other factors in OS. In conclusion, the findings of our current study indicate that BMI might play a role in the prognosis of female breast cancer in China, but the evidence was not strong enough. Citation Format: Yunqiu Dong, Franzel J. B. van Duijnhoven, Lu Wang, Ming Wu, Yun Qian, Ellen Kampman. BMI and other factors in relation to overall survival of female breast cancer in China [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3282.