Abstract
Background and aims: Traumatic brain injury (TBI) is the most common cause of death and acquired disabilities in children. To better plan support services for children and their families we need to be able to predict how the TBI will affect their functional outcome. Aims: The objectives of this study were to examine the associations between serum biomarkers and functional outcome in children with TBI. Methods: A prospective multicenter pilot observational study of children (5 to 17-years old) with TBI was conducted to examine the association between 11 serum biomarkers and unfavorable outcome at 12 months post-injury. Blood samples for biomarkers were collected daily.Table: No title available.Results: 30 children who were measured serum biomarkers within 24 hours post-injury were examined, and 5 of them showed unfavorable outcome (Pediatric Cerebral Performance Category change from baseline of 1 or more over 12 months). S100B, MBP, and NSE levels on day 1 were related to outcome. The prognostic values of these biomarkers were high with areas under the receiver operating curves of 0.79 to 0.93. Moreover, the pattern of change of some biomarkers, over several days, was also related to outcome.FigureConclusions: Serum biomarkers may be useful for predicting functional outcome after pediatric TBI.
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