Abstract
Abstract A fiber optic device has been developed with a maneuverable probe tip that sparges oxygen gas and photo-detaches pheophorbide (sensitizer) molecules. Singlet oxygen is produced at the probe tip surface which reacts with an alkene bridge causing the release of sensitizer upon fragmentation of a dioxetane intermediate. For optimal sensitizer release the probe tip was loaded with 0.3% sensitizer resulting, where crowding of pheophorbide molecules and self-quenching were kept to a minimum. The fiber optic device delivers pheophorbide molecules and singlet oxygen to discrete locations. Site-selective release of pheophorbide occurred in lipophilic media, it was quantitative in petrolatum (petroleum jelly, 100%), and was inefficient in toluene (5%) and water (<1%) due to poor the solvation. The results open the door to applications in tumor eradication in lipophilic and hypoxic structures requiring cytotoxic control. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3234. doi:10.1158/1538-7445.AM2011-3234
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