Abstract 3146: MFG-E8: A novel prognostic marker for gastric cancer

Abstract

Abstract Gastric cancer is one of the leading causes of cancer-related death all over the world. Milk fat globule-epidermal growth factor (EGF)-factor VIII (MFG-E8) was found to be highly unregulated in a variety of cancers, could induce phagocytosis of apoptotic cells and a significant factor in immune systems. However, its prognostic potential has not been evaluated in gastric cancer (GC). In our former proteomic study, MFG-E8 was found significantly overexpressed in gastric cancer tissues comparing with paired non-cancerous gastric tissues. This study aimed to analyze the association between the expression of MFG-E8 in GC tissues and clinical outcomes in GC patients. In this study, 3 independent cohorts (GSE15460, n = 192; TCGA, n = 380 and ACRG, n = 300) were used to assess MFG-E8 as a biomarker, Kaplan-Meier survival analysis showed that its overexpression was associated with poor prognosis of GC with good discriminative ability in 3 independent cohorts (GSE15460, P <0.001; TCGA, P <0.001 and ACRG, P <0.001). Multivariate analysis further confirmed its prognostic significance (GSE15460, P =0.028; TCGA, P <0.001 and ACRG, P =0.012). These results suggest MFG-E8 may become a potential prognostic factor for GC. Note: This abstract was not presented at the meeting. Citation Format: Sai Ge, Jing Gao, Lin Shen. MFG-E8: A novel prognostic marker for gastric cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3146.