Abstract
Aging is typically accompanied by increasing inflammation. It is assumed, based mainly on data of older adults younger than ninety years, that higher increases in inflammation are related with faster declines in functional health and psychosocial well-being. We set out here to extend these results to high-functioning Nonagerians, to better understand factors contributing to longevity. N = 125 participants between 90 and 100 years (mean = 91.85; 53.2% female) who were sufficiently mobile for a lab visit were enrolled. N = 105 provided blood samples for measurement of interleukin (IL)-6 and IL-10, and were interviewed to gather data on psychosocial well-being and functional health. Interleukin-6 ranged from 0.66 to 4.79 pg/ml (mean = 2.29), IL-10 ranged from 0.09 to 5.40 pg/ml (mean = 1.09). IL-6, but not IL-10 was correlated with age (r = 0.37; p 0.21; all p’s
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