Abstract
Abstract Background: Although the physiological functions of various phospholipases, such as lysophospholipase D (Autotaxin), has been extensively investigated, those of Phosphatidylserine-Specific Phospholipase A1 (PSPLA1), a kind of phospholipase involved in allergic reactions, has not been fully elucidated yet. Here, we evaluated the role of PSPLA1 in oncogenesis and tumor metastasis of colorectal cancer. Materials and Methods: Surgical specimens of 85 consecutive patients with colorectal cancer who received surgery in our department between January 2005 and December 2005 were immunostained with a monoclonal antibody to PSPLA1. The correlation between PSPLA1 expression and the clinico-pathological variables was analyzed by univariate and multivariate analyses. The impact of PSPLA1 expression on the prognosis of the patients was assessed, in comparison with the other clinico-pathological variables. Results: PSPLA1 expression significantly correlated with tumor size, tumor depth and hematogenous metastasis in univariate analysis, and tumor depth and hematogenous metastasis were independent variables in multivariate analysis. The disease-free survival (DFS) of patients with high-PSPLA1 expression was significantly shorter compared to those with low expression. The presence of hematogenous metastasis, however, was the only independent factor associated with poor DFS. Conclusion: PSPLA1 expression in colorectal cancer was associated with tumor invasion and metastasis. Citation Format: Yuuki Iida, Eiji Sunami, Soichiro Ishihara, Hironori Yamaguchi, Nelson H. Tsuno, Joji Kitayama, Toshiaki Watanabe. Phosphatidylserine-specific phospholipase A1 (PSPLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 31. doi:10.1158/1538-7445.AM2014-31
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