Abstract 309: Miniaturized Chest Compressor Improves Cerebral Perfusion Without Increases in Intracranial Pressure During Cardiopulmonary Resuscitation in a Porcine Model

Abstract

Introduction: Previously, we demonstrated that the miniaturized mechanical chest compressor (MCC) improved hemodynamic efficacy and the success of CPR. Currently, we investigated the effects of the same device on cerebral perfusion and intracranial pressure (ICP). Hypothesis: Mechanical chest compression with MCC would improve cerebral perfusion without increases in ICP during CPR. Methods: Thirteen male domestic pigs weighing 39 ± 3 kg were utilized. Ventricular fibrillation was electrically induced and untreated for 7 mins. The animals were then randomized to receive mechanical chest compression with the MCC (n=7), or the Thumper device (n=6). Defibrillation was attempted after 5 mins of CPR. If resuscitation was not successful, CPR was resumed for 2 mins prior to the next defibrillation until either successful resuscitation or for a total of 15 mins. Results: During CPR, significantly greater mean cerebral perfusion pressure was produced by the MCC when compared with the Thumper device. However, there was no significant difference in mean ICP. Interestingly, diastolic ICP was significantly lower in the MCC group, which was closely related to the significantly lower negative intrathoracic pressure in the animals that received the MCC (Table). Conclusion: During CPR, mechanical chest compression with MCC significantly improved cerebral perfusion without increases in ICP.