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Abstract
Abstract Head neck cancer (HNC) is a top ten leading cancers in Taiwan. Since this cancer usually occurs in the middle age male, at the high peak of life responsibility, it has tremendous impact of family and society. Previously through differential display analysis, we have identified several genes associated with HNC including NDRG1 (N-myc downstream-regulated gene-1), which is over-expression in HNC. In the present study, we further investigate cellular function of this gene leads to cancer development. NDRG1 expression was modulated by shRNA and full-length plasmid transfection and the potential alterations of cellular phenotypes were examined. Results showed that NDRG1 suppressed cell growths by 14% to 55%. This phenomenon was confirmed by colony formation. However, by using wound healing assay the cell migration increased (17% ∼ 43%) and by using matrigel invasion assay the invasion increased (7 ∼ 12 folds). Both migration and invasion were significantly enhanced. These results suggest that NDRG1 plays dual functions in tumorigenesis with multiple aspects Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3045. doi:10.1158/1538-7445.AM2011-3045
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