Abstract
Background and Purpose: Chronic hypoperfusion associated with high grade intracranial atherosclerosis may results in regional atrophy. This study was performed to determine the effect of intracranial stenosis on ipsilateral regional cerebral volume. Methods: We included patients with intracranial stenosis >50% in the anterior circulation who underwent brain magnetic resonance image (MRI) who were admitted to a University hospital. The severity of intracranial atherosclerosis was evaluated by angiography and degree of stenosis was calculated using the WASID criteria. MRI images were acquired with a 1.5-T MR scanner and fluid attenuated inversion recovery (FLAIR) images were used for volumetric analysis. Volumetric analysis was performed by a single observer with the ANALYZE 9.0 software package. Hemispheric supratentorial volume was defined as hemispheric volume (HV) and included a cumulative value of grey and white matter volumes in frontal, parietal, and occipital lobes. Results: A total 42 hemispheres in 21 patients (12 men, mean age±standard deviation 56.4±16.2 years) with intracranial stenosis were studied. There was no statistical difference of HV in between non-stenotic and stenotic side (491.7±62.6 vs 486.7±57.8 cm3, p=0.3953, t-test). There was no statistical difference of HV in between moderate stenosis (50∼75%) and severe stenosis (>75%) (480.6±56.7 vs 490.5±60.4 cm3, p=0.3657, t-test). However, in regression analysis, difference between both HV (non stenotic-side - stenotic side HV) within individuals significantly correlated with degree of stenosis (R2=0.27, P=0.0152). Conclusion: The patients with intracranial stenosis of anterior circulation appear to have an asymmetry in regional cerebral volume directly related to the severity of stenosis. This observation supports the concept that regional cerebral atrophy may be seen with intracranial stenosis.
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