Abstract
Abstract The incidence and death rate for pancreatic cancer, the fourth leading cause of cancer death in the U.S., have been increasing. Excess weight through adulthood is one of the few modifiable risk factors for pancreatic cancer. Childhood obesity rates have increased more rapidly that adulthood obesity in the U.S, but its effects on pancreatic cancer risk are not clear. Hence, the objective of this study is to test the hypothesis that childhood weight is associated with pancreatic cancer risk later in life. We evaluated the association of body mass index (BMI) measured at ages 7-13 with risk of pancreatic cancer later in life in 288,423 children from the Copenhagen School Health Records Register who were born between 1930-1981. These data were linked with the Danish Cancer Registry to identify incident pancreatic cancer cases from 1977-2011. Follow-up ended on the date of pancreatic cancer diagnosis, death, emigration, 70th birthday, or December 31st 2010, whichever came first. Hazard Ratios (HR) and 95% confidence intervals (CI) were calculated for age specific BMI z-scores using Cox proportional hazards stratified on birth cohort and gender. Restricted cubic splines analysis was used to test for linearity. There were 1163 pancreatic cancer cases during the 6,918,420 person-years of follow up. Childhood BMI was associated with pancreatic cancer risk in males and females. At age 10, for example, HR per one unit increase in BMI z-scores was 1.17 (CI: 1.08, 1.26). The observed association did not deviate from linearity. Our results support the hypothesis that higher childhood body weight is associated with increased pancreatic cancer risk later in life. Citation Format: Leticia M. Nogueira, Rachael Stolzenberg-Solomon, Michael Gamborg, Thorkild Sørensen, Jennifer Baker. Childhood BMI is associated with risk of adult pancreatic cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2916. doi:10.1158/1538-7445.AM2014-2916
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