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Abstract
Background: Congenital Adrenal Hyperplasia (CAH) is complicated by central precocious puberty in children which may compromise the final height.Aim: We aim to evaluate the effect of gonadotropin analog (GnRH) therapy on final height in children with CAH.Results: 8 children with CAH with advanced height and bone age and LH, either basal or stimulated, in pubertal range were included in study. GnRH analog 3.75 mg was administered every 4 weeks. Median follow up period was for 2 years. Height age and bone age was noted every 6 months and predicted adult height was calculated at the beginning and end of the treatment using Bayley and Pinneau method. Median growth velocity was 4 cm and 3.75 cm at the end of first and second year. Predicted adult height was increased by 10 cms at the end of 2 years of treatment.Conclusion: GnRH therapy significantly augments linear growth and bone age advancement in children with CAH complicated by central precocious puberty.
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