Abstract 28: Health Care Cost Burden of Infective Endocarditis in United States: A Nationwide Study

Abstract

Introduction: Aging population and recent opioid epidemic have contributed to increase incidence and cost of Infective endocarditis (IE). We aimed to assess health care burden of IE using nationally representative derived data that is designed for inpatient health care cost and utilization. Methods: Using the National inpatient sample (NIS), we examined 591,871 hospitalizations with a diagnosis of IE from 2002 to 2016. Risk Adjusted rates were calculated using univariate generalized logistic model for analysis of co variance. Trends were assessed with Linear regression and Pearson’s Chi square when appropriate. Results: Mean age of admission was 59.2[SD;18.8]. Females represented 40.9% (242,024 of 591871) of admissions. The proportion of patients with history of drug use increased from 11.5% (3,361 of 29,226) in 2002 to 23.1% (12,385 of 53,615) in 2016. We noticed an overall downtrend in mortality, from 16.4% (4,450 of 27,134) in 2002 to 8.8% (5,370 of 61022) in 2016. There was also a downtrend in the mean length of stay (16.2 days in 2002 to 14.2 days in 2016, p<0.01) but increase in the adjusted for inflation average cost ($100,643 in 2002 to $168,734 in 2016, p<0.01). There was also an increase in hospital-based procedures like valvular surgery. Conclusion: In-hospital mortality from IE has been on a decline but total hospitalization and average cost of stay in IE has increased. The reasons behind this warrant further investigation.