Abstract 2768: Ribosome biogenesis score: Prognostic insights and drug responses in cancer

Abstract

Abstract Ribosome biogenesis, a crucial cellular process responsible for creating the cellular machinery required for protein synthesis, is vital for cell growth and proliferation. Cancer cells have dysregulated ribosome biogenesis, which contributes to uncontrolled cell growth and proliferation. Aberrant ribosome biogenesis not only drives the increased need for protein synthesis in rapidly developing cancer cells, but it also orchestrates tumor-related signaling cascades. We developed a robust scoring method for ribosome biogenesis and applied it to a broad range of TCGA tumor samples. By categorizing TCGA samples into distinct groups based on their ribosome biogenesis scores, we unveil significant prognostic associations in various cancer types. We used the scoring method and compared the scores with ssGSEA analysis using different ribosome biogenesis signatures in several databases to confirm these predictions. Furthermore, our research goes beyond predictive implications, delving into the biochemical complexities of ribosome biogenesis's impact on drug responses and resistance. This thorough investigation sheds light on the molecular complexities of ribosome biogenesis in tumors, providing useful insights with potential implications for refining strategies for cancer therapy. Citation Format: Amr R. Elhamamsy, Rajeev S. Samant, Lalita A. Shevde. Ribosome biogenesis score: Prognostic insights and drug responses in cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 2768.