Abstract 2597: Prospective study of the relationship between coffee and tea with colorectal cancer risk: The PLCO cancer screening trial.

Abstract

Abstract Coffee and tea are commonly consumed and carry several potential anticancer components which could reduce the risk of colorectal cancer risk; however, the relationships of coffee and tea consumption with colorectal cancer risk remain unclear. We prospectively examined the relations of coffee and tea intake to colorectal cancer risk in 53,480 men and women in the intervention arm of the NCI-Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. The majority of these men and women (82.3%) received flexible sigmoidoscopy screening at baseline. Coffee and tea intakes were assessed by a food frequency questionnaire at study baseline. Six-hundred and twenty-two incident colorectal cancer cases were ascertained during a median follow-up of 11.4 years. Greater coffee intake was not associated with risk of colorectal cancer. The relative risks for <1 cup/day, 1 cup/day, 2-3 cups/day and ≥4 cups/day, respectively, were 0.89 (95% CI=0.65-1.20), 0.92 (95% CI=0.68-1.25), 1.02 (95% CI=0.76-1.36) and 1.08 (95% CI=0.78-1.49); p for trend = 0.16. Associations were also not detected for ≥4 cups of coffee/day when stratifying by cancer site (proximal, distal and rectal, p for heterogeneity = 0.53) or stage of disease (stage I, stage II and stage III/IV, p for heterogeneity = 0.86). Furthermore, associations remained unchanged in subsets of participants for either caffeinated or decaffeinated coffee or when stratifying by several colorectal cancer risk factors. Similarly, greater tea intake was not associated with colorectal cancer risk. The relative risks for <1 cup/day, 1 cup/day and ≥2 cups/day were 1.02 (95% CI=0.82-1.27), 1.14 (95% CI=0.83-1.58) and 0.76 (95% CI=0.53-1.10), respectively; p for trend = 0.15. There were also no associations observed for ≥2 cups of tea/day by cancer site (proximal, distal and rectal, p for heterogeneity = 0.79) or stage of disease (stage I, stage II and stage III/IV, p for heterogeneity = 0.44). The associations were also not modified by several colorectal cancer risk factors. In conclusion, the findings of this study do not provide evidence to suggest that drinking coffee or tea is beneficial in protecting against colorectal cancer. Citation Format: Christine Dominianni, Wen-Yi Huang, Sonja Berndt, Richard B. Hayes, Jiyoung Ahn. Prospective study of the relationship between coffee and tea with colorectal cancer risk: The PLCO cancer screening trial. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2597. doi:10.1158/1538-7445.AM2013-2597