Abstract
Abstract IFNα is an immune-regulatory cytokine, used clinically for the treatment of various cancers. Administration of recombinant IFNα or IFNα-inducing agents in cancer patients induce the activation/expansion of NK cells and tumor-specific CTL responses, leading to tumor regression. Here, we find that the Polythymine (poly-T) oligonucleotides (ODN) induce the production of IFNα. Current results indicated the intratumoral injection of poly-T ODN could slow the growth of tumors and enhance the tumor specific CTLs. Our results shows a synthetic ODN containing Poly T motif have anti-tumor effect through the enhancement of IFNα production. Citation Format: Nobuaki Kobayashi, Hidekazu Shirota, Yoko Ichiki, Kiyoshi Sakasai, Yasushi Ichikawa, Takeshi Kaneko, Yoshiaki Ishigatsubo. Polythymine oligonucleotides inhibit tumor growth through the induction of IFN alpha. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2576. doi:10.1158/1538-7445.AM2014-2576
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