Abstract
Abstract Pegylated chlorin e6 photosensitizers have been synthesized with triethylene glycol attached at the ester bond(s) for a 1:1 conjugate, a 2:1 conjugate, and a 3:1 conjugate. These chlorin sensitizers were studied for hydrolytic stability and solubility. Our studies included an analysis of ovarian OVCAR-5 cancer cell uptake, localization, and phototoxicity. Because of our interest in fiber-based photosensitizer and singlet oxygen delivery methods, desirable aspects of the 3:1 chlorin e6 conjugate make it a potential sensitizer for incorporation into a fiber optic device, particularly in the area of ovarian cancer photodynamic therapy. Citation Format: Ashwini Ghogare, Goutam Ghosh, Stanley Kimani, Dorota Bartusik, Benjamin Rudshteyn, Tayyaba Hasan, Alexander Greer. Synthesis and characterization of PEGylated chlorin e6 sensitizers for the photodynamic killing of human ovarian cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2481. doi:10.1158/1538-7445.AM2013-2481
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