Abstract
Abstract Intravital imaging windows are powerful tools for long-term visualization of dynamic cell behaviour in living mice. However, the applications of the current windows are limited because they cannot be used for imaging of organs in the abdomen. In order to overcome this unmet need, we developed the abdominal imaging window (AIW). Using the AIW, we visualized stem cells in the small intestine, lymphocytes in the spleen, transplanted islets of Langerhans under the kidney capsule, and metastatic outgrowth of tumor cells in the liver. We discovered that liver metastases are grown from a single founder cell, and that tumor cells within a growing metastasis are highly motile. Strikingly, this migration appears to be a novel, limiting step during liver metastasis formation. We conclude that the AIW is a powerful tool to visualize distinct biological processes in a variety of abdominal organs with subcellular resolution over a time span of weeks. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2429. doi:1538-7445.AM2012-2429
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