Abstract 238: Gender Differences In Clinical Factors In Obese Ischemic Stroke Patients With A History Of Smoking

Abstract

Introduction Clinical risk factors and co‐morbidities in obese male and female ischemic stroke patients with a history of smoking may contribute to differing stroke outcomes. The objective of this study is to determine gender differences in risk factors in obese ischemic stroke patients with a history of smoking. Methods A retrospective study was conducted on 6‐year data from 5469 patients with an ischemic stroke event from a regional stroke center. A logistic regression model was used to predict clinical risk factors associated with male or female patients. Multicollinearity was assessed using variance inflation factors (VIFs), with values >5 suggestive of multicollinearity Results In the adjusted analysis, (OR = 1.806, 95% CI, 1.028–3.174, P =0.040*), a history of drugs and alcohol (OR = 2.873, 95% CI, 1.349–6.166, P =0.006), Serum Creatinine (OR = 4.724, 95% CI, 2.171–10.281, P<0.001), Age (OR = 1.024, 95% CI, 1.022–1.047, P=0.033), and systolic blood pressure (OR = 1.029, 95% CI, 1.011–1.047, P<0.002) were associated with males. Depression (OR = 0.432, 95% CI, 0.244–0.764, P<0.004), Previous TIA (OR = .319, 95% CI, 0.142–0.714, P<0.005), and higher levels of HDL (OR = 0.938, 95% CI, 0.915–0.962, P<0.001) were associated with female gender. Conclusion Gender differences were observed in the clinical factors and comorbidities within the population of AIS patients who were smoking and obese. Further studies should evaluate the effect of specific risk factors to develop specific strategies for the management of identified risk factors to improve the care of obese male and female ischemic stroke patients with a history of smoking.