Abstract 2340: Evaluation of metabolic and hormonal disorders in Yemeni women with breast cancer attending national oncology center in Mukalla, Yemen

Abstract

Abstract Background: Metabolic syndrome has been linked to many adverse health consequences, including breast cancer. This study aimed to evaluate the metabolic and hormonal disorders and assess the effect on estrogens in Yemeni women with breast cancer. Patients and Methods: A total of 69 Yemeni women with breast cancer were recruited into the cross-sectional study. This study was conducted at the National Oncology Center in Mukalla, Yemen, from15th March to 30th July 2021. Anthropometric data and blood pressure were taken from each participant. Fasting blood glucose FBG, HbA1c, lipid profile, C-reactive protein (CRP), were measured using the chemical autoanalyzer (Mindray Bs230 autoanalyzer, Mindray Diagnostics). Insulin, estradiol, and testosterone were measured using Mindray CL-960i, Mindray Diagnostics ). Data were analyzed by using SPSS. Results: The mean age of the participants was 48.17±11.0 years. The majority were normal weight(40.6%), and some were obese (30.4%) and overweight (29.0%). The majority had breast cancer stage2 (53.6%), and some were stage 4 (24.6%) and stage 3 (21.7%). Obese breast cancer women had significantly higher weight (P<0.001), BMI (P<0.001), waist (P<0.001), and hips (P<0.001) than the normal weight group. Furthermore, obese breast cancer women had significantly higher HbA1c(P=0.016), TC (P<0.001), and LDL-C (P=0.032) than the normal weight group. Insulin was positively associated with FBG (P=0.001) and HOMA-IR (P<0.001). Estradiol was positively associated with total cholesterol (P=0.004), triglycerides (P=0.007), and CRP (P=0.026). testosterone was negatively associated with CRP (P=0.011) and estradiol (P=0.019) in the combined groups studied. Conclusion: Metabolic syndrome is more prevalent in breast cancer patients and is more likely to develop breast cancer. Citation Format: Lotfi Saeed Bin Dahman, Zaki Farag Sanoon, Waleed Khalid Kaleem, Mariam Ahmed Humam, Shaima Adeeb Bamhraz, Noor Adeeb Bamatraf, Khadija Mohmmed Humran, Fatima Lutfi Albada, Yaser Saeed Obad. Evaluation of metabolic and hormonal disorders in Yemeni women with breast cancer attending national oncology center in Mukalla, Yemen [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2340.