Abstract 225: Relationship Between Blood Pressure Lowering Medication Profiles and Coronary Artery Disease in Patients With Acute Chest Pain

Abstract

Introduction Whether use of blood pressure lowering medications (BPLMs) is associated with presence and severity of coronary artery disease (CAD) is unknown. The aim of this study was to examine the relationship between BPLMs and coronary artery calcium score (CACS) as a marker of CAD in patients with acute chest pain. Methods In this cross-sectional study, 1030 consecutive patients without reported history of CAD who presented with acute chest pain were included. CACS by non-contrast multi-detector computed tomography scan, BPLMs profiles prior to the visit were collected. Patients were categorized by presence and severity of CACS, number and classes of BPLMs used. Results The population with mean age of 54±13 years consisted of 60.6% (624 of 1030) patients with zero CACS, 21.7%(223 of 1030) with mild calcification(0<CACS<100) and 17.8%(183 of 1030) with moderate-to-severe calcification(CACS≥100). Patients with single BPLM and multiple BPLMs are accounted for 24% and 24% of all the patients respectively. Compared to non-BPLM group, BPLMs group had more patients with presence of CACS and moderate-to-severe calcification (238 of 494; 48.2% vs 168 of 536; 31.3% p<0.001; for CACS>0 and 118 of 494; 23.9% vs 65 of 536;12.1% p<0.001;for CACS≥100). Compared to single BPLM group, multiple BPLMs group had no significant difference in numbers of patients with presence of CACS and moderate-to-severe calcification (p=0.106 and p=0.345 respectively). Most BPLMs classes are associated with CACS as shown in table1. Conclusion Use of blood pressure lowering medications is associated with presence and severity of coronary artery disease in patients with acute chest pain.