Abstract 2243: Cell-phone radiofrequency enhances angiogenesis and stimulates cell invasion of human head and neck cancer cells

Abstract

Abstract Today, cell-phone is the most widespread technology globally. It has been suggested that cell-phone radiofrequency (RF) use may increase the risk of human brain and probably head cancers. However, the outcome of cell phone RF on head and neck (HN) cancer progression has not been explored yet. Thus, first we examined the outcome of cell-phone RF on angiogenesis using the chorioallantoic membrane (CAM) of the chicken embryo as a model. Then we investigated the effect of cell-phone RF on cell invasion and colony formation in soft agar of two human HN cancer cell lines. Our data revealed that cell-phone RF promotes angiogenesis of the CAM. In addition, cell-phone RF enhances cell invasion and colony formation of human HN cancer cells; this is accompanied by a down-regulation of E-cadherin expression. Regarding the mechanism of cell-phone RF on angiogenesis, cell invasion and colony formation, we found that cell-phone RF activates Erk1 and Erk2 in our experimental models which could be the main pathway behind these events. These data suggest that cell-phone RF enhances HN cancer progression by stimulating angiogenesis, cell invasion and tumor formation via Erk1 and Erk2. Citation Format: Ala-Eddin Al Moustafa. Cell-phone radiofrequency enhances angiogenesis and stimulates cell invasion of human head and neck cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2243.