Abstract
Abstract The Genotype-Tissue Expression (GTEx) project is an NIH Common Fund study that is aimed at understanding how genetic variation influences gene expression in normal tissues. Here we describe a biospecimen collection platform that was developed to address the logistical challenges of acquiring a large collection of high-quality tissues from rapid autopsy and organ donors for GTEx. This complex infrastructure is utilized to procure specimens under a rigorous quality management program and a stringent ethical, legal, and regulatory framework. Ultimately, data from the GTEx study will be used to evaluate gene regulatory mechanisms and their contribution to human disease development. Citation Format: Latarsha Carithers, Abhi Rao, Helen Moore. Acquisition of biospecimens to support the Genotype-Tissue Expression (GTEx) project. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2237. doi:10.1158/1538-7445.AM2014-2237
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