Abstract 223: Pilot Study of s Rewarming Rate of 0.15c/h vs. 0.25c/h and Outcome in Post Cardiac Arrest Patients

Abstract

Introduction: Cerebral hemodynamic and metabolic changes may occur during the rewarming phase of targeted temperature management (TTM) of post cardiac arrest patients. Yet, studies of different rewarming rates and patient outcomes are limited. The researchers would like to perform a pilot study to investigate post cardiac arrest patients, who were rewarmed with different rewarming rates after 24 hours of hypothermia and their association to neurologic outcomes. Method: The researchers investigated post cardiac arrest patients treated with TTM and rewarmed with a rewarming rate of 0.15°C/h and 0.25°C/h. The association of rewarming rate and poor neurologic outcome(CPC3-5) was investigated. Result: A total of 63 patients were analyzed (0.15°C/h N=33, 0.25/h N=30). When comparing the neurologic outcomes of 0.15°C/h versus 0.25°C/h, the neurologic outcome did not significantly differ between the two rewarming rates (22(66.7) vs. 20 (66.7), p=1.00). Rewarming rate of 0.15°C/h was not associated with one-month neurologic outcomes, after adjusting confounding factors in the multivariate analysis (OR 1.19 (0.31-4.54), p=0.80). Conclusion: Although the sample size was limited, findings of this pilot study showed that rewarming rates of 0.15°C/h and 0.25°C/h were not associated with different neurologic outcomes in the post cardiac arrest patients.