Abstract 2204: Loss of heterozygosity in ameloblastic odontogenic tumors

Abstract

Abstract The interrelationship of the odontogenic lesions consisting of odontogenic epithelium with odontogenic ectomesenchyme has not been established. To give further insight into the molecular pathogenesis of these odontogenic tumors, the present study investigated allelic loss of a panel of tumor suppressor genes. Six samples of ameloblastic fibroma (AF), 3 cases of ameloblastic fibro-odontoma (AFO) and 3 ameloblastic fibrosarcomas (AFS) were included in the study. We observed loss of heterozygosity (LOH) in 2/6 samples of AF in at least one of the analyzed markers and loss in all the three samples of AFO and AFS in more than one marker. Results are shown in table 1. For the markers AFM238WF2(CHRNB1) and P53, LOH was found all the three types of lesion studied. However, the markers D3S1293, D9S157 and D9S171 showed LOH only in AFS and none of the samples included in the study showed LOH of D11S1369 and D3S1029 markers. LOH was observed for the marker D9S162 in only one sample of AFO. Our data show that AFS have distinct patterns of LOH in tumor suppressor genes compared to their benign counterparts and allelic loss of some markers may be related to tumor behavior, as AFS is a malignant odontogenic tumor and the others are benign entities. This study was supported by FAPEMIG and CAPES, Brazil. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2204. doi:10.1158/1538-7445.AM2011-2204