Abstract 2186: Incorporation of natural compounds into biomaterials to prevent breast cancer recurrence

Abstract

Abstract Numerous studies have demonstrated that naturally occurring phytochemicals such as Tannic acid (TA) possess anti-cancer properties. Apoptotic activity is increased in breast cancer and prostate cancer cells in response to exposure to tannin extracts. Collagen type I is a biomaterial routinely used for cosmetic and reconstructive surgeries, including breast reconstruction following breast cancer mandated surgeries. TA functions as a collagen crosslinking agent through both hydrogen bonding and hydrophobic effects. Thus, if TA-crosslinked collagen type I is used for breast reconstruction procedures, the crosslinked collagen will be remodeled by growing breast epithelial cells and adipocytes where the incorporated TA will be released killing nearby residual cancer cells preventing recurrence. When adipocytes are grown on TA-crosslinked collagen beads the measureable released TA induces caspase-mediated apoptosis in ER+ and HER2+ breast cancer cells but has no effect on triple negative breast cancer cells and reduced apoptotic-inducing activity in normal breast epithelial cells. We are developing an injectable matrix comprised of TA-crosslinked collagen beads and adipocytes to serve as a tissue regeneration platform in patients post-lumpectomy. Variables such as collagen temperature, syringe pump rate, and drop distance have been studied to determine ideal method for producing beads of the desired size and shape. These promising results will lead to the construction of a matrix designed to not only promote tissue regeneration but also simultaneously help to prevent tumor recurrence. This matrix provides protection in breast cancer patients and holds promise for patients suffering from other soft tissue cancers. Citation Format: Lauren Jordan, Bailey-Jean Walker, Christopher Moody, Brian W. Booth. Incorporation of natural compounds into biomaterials to prevent breast cancer recurrence. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2186.