Abstract 2122: RNA editing reveals new regulatory functions in tumorigenesis

Abstract

Abstract RNA Editing is a widespread post-transcriptional event that could increase the diversity of transcriptome. In humans, the most common type of RNA editing is adenosine-to-inosine (A-to-I) editing which is catalyzed by a family of enzymes called adenosine deaminase acting on RNA (ADARs). Over 90% A-to-I RNA editing sites locate in Alu elements, the most abundant transposable elements in human genome. We picked up 83 CEU individuals and 89 YRI individuals for RNA editing analysis. 94,315 credible sites are obtained after series of strict computational procedures. Those genes whose transcripts harbor numerous RNA sites are found to be enriched in several cancer-related pathways such as small cell lung cancer pathway, p53 signaling pathway and apoptosis pathway. Our work provides new insight into the regulation mechanism of RNA editing acting on tumorigenesis. Citation Format: Landian Hu. RNA editing reveals new regulatory functions in tumorigenesis. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2122. doi:10.1158/1538-7445.AM2015-2122