Abstract
Introduction: It has been reported that sympathetic nervous dysfunction by 123I-metaiodobenzylguanidine (MIBG) is associated with worse outcome in dilated cardiomyopathy (DCM) patients. However, the association between sympathetic nervous function and myocardial strain is not established. Hypothesis: Global longitudinal strain (GLS) by two-dimensional speckle-tracking echocardiography (2DSTE) is correlated with sympathetic nervous activity, and stratifies DCM patients at risk for cardiac events with a combination of sympathetic nervous activity. Methods: We studied 71 patients who had admitted to a cardiology department with heart failure at the initial visit (age 61±13 years, 45 males, LV ejection fraction (EF) 30±8 %). All patients underwent MIBG imaging for the delayed heart to mediastinum ratio (H/M), and echocardiography with conventional assessment including left atrial volume (LAV), LV end-diastolic and end-systolic volume (LVEDV, LVESV), LVEF, mitral regurgitation grade (MR), early transmitral flow to atrial contraction (E/A) and with 2DSTE analysis for GLS expressed with an absolute value. Cardiac events were assessed according to death and hospitalization with heart failure. Results: There were 21 cardiac events in the follow-up period for 4.9±2.3 years. Univariate regression analysis showed LAV, LVEDV, LVESV, LVEF, MR, E/A and GLS had a significant correlation with delayed H/M (all p < 0.05). Multivariate regression analysis revealed that GLS was an independent predictor of delayed H/M. Dividing all patients into 4 groups by the median of GLS in patients with delayed H/M >1.6 or≤1.6, the combination of the worse delayed H/M and the worse GLS was significantly associated with cardiac events (p=0.03). Conclusions: Left ventricular GLS is significantly correlated with delayed H/M and can be useful to stratify the risk in DCM patients with a combination of delayed H/M.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
