Abstract
In rheumatoid and collagen-induced arthritis (CIA) relative insufficiency of adrenal glands (AG) in later stages of the disease is known. Additionally, migration of macrophages and dendritic cells (DCs) into AG has been described. We hypothesized that these cells contribute to inadequate glucocorticoid secretion. CIA was induced in DA rats. Cytokines in supernatants from whole AG cells, AG cells after magnetic bead separation for macrophage/DC markers MHCII and CD11b, and from bone marrow-derived DCs (BMDC) were quantified with ELISA. The corticosterone secretion from whole AG cells in co-culture with BMDCs was quantified with ELISA. BMDCs generated from arthritic rats expressed significantly more IL-1b, CINC-1,-2,-3, and LIX (all p
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