Abstract
Abstract MultiCellular Tumor Spheroid (MCTS) mimic the organization of a tumor and is considered as an invaluable model to study cancer cell biology and for the preclinical development of new antiproliferative drugs. We will report how engineering of MCTS in association with new technological developments can be used to explore the regionalization and the effects of novel drugs. We will demonstrate the potential of these 3D models to study the kinetics aspects of the response on live spheroids expressing fluorescent reporters and markers using light sheet microscopy (SPIM). We will also report the development of innovative microdevices dedicated to the study of the dynamics of MCTS formation and to the monitoring of mechanosensing and tumor growth-induced mechanical stress. We will present our latest advances on the characterization of these processes and on the use of these assays for the identification of new original targets and compounds. Citation Format: Bernard Ducommun, Valérie Lobjois. Multicellular tumor spheroid 3D models to decipher cancer cell biology and to evaluate anticancer drugs. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2025. doi:10.1158/1538-7445.AM2014-2025
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