Abstract
Aims: The study was performed in search of a novel contrast agent, which has non-renal excretion. Contrast induced nephropathy and cardiogenic shock resulting in renal failure are common problems. A novel contrast with non-renal excretion is very useful. Materials and Methods: Magnetic nanoparticles were synthesized and it was conjugated with commercially available Iodixanol. The particle size measurement showed size of about 220nm. The conjugation was performed to result in covalent bonding. Final concentration of nanoparticles was 1mg in 1 ml. Thereafter the contrast was tested for radio-opacity. Magnetic properties of the contrast were tested with magnets. A drop of contrast was tested over magnets and over a glass slide. The droplet on the magnet fixes and retains the shape and the bubble structure in various positions of the magnet manipulation. Over a glass slide it showed free movement and loses the bubble structure. Figure shows bubble evaluation and cine-fluoroscopy. Conclusion: Magnetic nanoparticle conjugated Iodixanol shows potentials as a novel contrast agent for use in the future.
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