Abstract 2: Prognostic significance of POLE exonuclease domain mutations in high grade endometrioid endometrial cancer on survival and recurrence

C.C Billingsley,E.M Hade,D.E Cohn,D.G Mutch,P.J Goodfellow

doi:10.1016/j.ygyno.2015.03.019

Abstract 2: Prognostic significance of POLE exonuclease domain mutations in high grade endometrioid endometrial cancer on survival and recurrence

C.C Billingsley, E.M Hade + Show 3 more

https://doi.org/10.1016/j.ygyno.2015.03.019

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Journal: Gynecologic oncology

Publication Date: May 23, 2015

Affiliation: The Ohio State University, University of Washington

#High Grade Endometrioid Endometrial Cancer #POLE Exonuclease Domain Mutations + Show 8 more

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Abstract

Objectives: POLE exonuclease domain mutations have previously been described to occur in the tumors of endometrial cancer (EC) patients, and result in the inability to repair mismatched bases during DNA replication. The prognostic impact of these mutations is controversial. We sought to investigate the prevalence of POLE mutation tumor status and its prognostic significance on survival and recurrence outcomes in women with high grade endometrioid EC.

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