Abstract 1989: Gene expression signature of the non-cancerous liver tissue associated with the early recurrence of hepatocellular carcinoma

Abstract

Abstract Recurrence of hepatocellular carcinoma (HCC) might be associated with biological aggressiveness of the cancer as well as background status of the liver. In this study, the predictive values for the early recurrence were assessed on patients with HCC after curative hepatectomy using clinicopathological factors and genome-wide gene expression signatures. Multivariate analysis of clinico-pathological factors revealed portal vein invasion (p=0.007), hepatitis C virus infection (p=0.001), and low levels of serum albumin (p=0.003) as the risk factors, yielding a ROC-plot AUC value of 0.854 with 61.5% sensitivity and 81.8% specificity. Analysis of the gene expression profiling on the cancer tissues of HCC revealed the significant differences in CD24 stem cell marker and MTSS1 metastasis suppressor molecule. The cancer six-gene signature for the prediction of recurrence yielded a ROC-plot AUC value of 0.897 with 81.8% sensitivity and 88.5% specificity. Using the non-cancerous liver tissues surrounding HCC, distinct differences were recognized by the gene expression profiling such as IGL immunoglobulin lambda light chain and MAP2K1 mitogen-activated protein kinase kinase. The non-cancer six-gene signature yielded a ROC-plot AUC value of 0.966 with 84.8% sensitivity and 88.5% specificity for the prediction of HCC recurrence. These gene expression signatures can be involved in the metastatic potentials of the invasive HCC, and the multi-centric hepatocarcinogenesis, respectively. Our results might indicate the molecular targets for prediction and/or treatment of the recurrence, as well as the super-high risk group of HCC within the patients with hepatitis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1989.