Abstract 1985: ZNF783, a novel zinc finger protein has tumor suppressor function in prostate cancer.

Abstract

Abstract In the last decade hypermethylation of promoter regions has been accepted to be a prominent feature of human tumorigenesis by silencing tumor suppressor genes and other genes involved in cellular pathways. To study more in depth the involvement of aberrant methylation in prostate cancer tumorigenesis, we used a genome wide methylation array from Illumina (Infunium) to identify novel hypermethylated genes that might contribute to prostate cancer progression. ZNF783 is one such candidate gene. ZNF783 is Zinc-finger transcription factor that maps to human chromosome 7q33, a region implicated in prostate cancer tumorigenesis. We have observed significant hypermethylation of ZNF783 promoter CpG island in prostate cancer cell lines and prostate tumors when compared to match normal prostate tissue samples from radical prostatectomy patients. The treatment of prostate cancer cell lines with pharmacological demethylating agents restored ZNF783 gene expression indicating a role for epigenetic DNA methylation in regulating ZNF783 expression in prostate cancer. The ZNF family of proteins has been identified to play essential roles in gene expression/regulation including inhibition of cell cycle proliferation, differentiation and apoptosis. The current study demonstrates a potential tumor suppressor role for ZNF783 in prostate cancer cells. Citation Format: Rana Tbaishat, Songping Wang, Bernard Kwabi-Addo. ZNF783, a novel zinc finger protein has tumor suppressor function in prostate cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1985. doi:10.1158/1538-7445.AM2013-1985