Abstract
Abstract We report here imaging of stroma during the metastatic process. RFP-EL4 lymphoma cells were injected subcutaneously in C57/BL6 GFP transgenic mice. Subcutaneous tumors were resected and immediately transplanted to the abdominal cavity of BALB/c nude mice. Metastases to the liver, perigastric lymph node, ascites, bone marrow and as well as the primary tumor were imaged. Metastases expressed GFP at low magnification. At higher magnification, yellow-remaining cancer cells resulting from fusion of GFP stromal cells and RFP cancer cells were observed. Metastasis contained fusion of caner and stromal cells which may be a feature of metastasis. Citation Format: Miki Nakamura, Atsushi Suetsugu, Kousuke Hasegawa, Takuro Matsumoto, Hitomi Aoki, Takahiro Kunisada, Masahito Shimizu, Shigetoyo Saji, Hisataka Moriwaki, Robert M. Hoffman. Fusion of cancer and stromal cells imaged by color -coded imaging of metasasis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1980. doi:10.1158/1538-7445.AM2017-1980
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