Abstract 19385: Postprandial Hypotension, is it Real? The Preliminary Results of a Pilot Study

Abstract

Introduction: Postprandial hypotension is an important hemodynamic abnormality but it is very under-recognized. We performed this pilot study to evaluate the prevalence of postprandial hypotension and the possible associations between postprandial blood pressure (BP) decline and other forms of BP variability in type 2 diabetes. Methods: We enrolled 21 patients with type 2 diabetes. All patients were examined with ambulatory BP monitoring and we recorded every meal time. Postprandial hypotension was defined as a systolic BP fall of at least 20 mmHg compared with baseline BP level. Results: Mean age was 64.4±11.8 years and 11 patients were female (52.4%). Overall systolic BP and diastolic BP are 127.4±13.2 mmHg and 73.4±9.8 mmHg. Overall systolic BP variability was 13.7±5.5. Average postprandial BP fall was 13.9±10.7 mmHg and the BP fall was most conspicuous after breakfast. Fourteen patients (67%) were experienced postprandial hypotension by definition. Among them, 6 patients (43%) were non-dipper, 5 patients (36%) were reverse dipper and a patient was extreme dipper. Average systolic BP variability was significantly higher in the patients with postprandial hypotension (15.1±6.2 vs. 10.9±1.9, P=0.02). Conclusions: Postprandial hypotension is common in type 2 diabetes and there is possible relationship between postprandial hypotension and other abnormal BP patterns. To clarify the clinical significance of postprandial hypotension, large sized long term prospective study is needed.