Abstract 19204: Higher Physical Activity and Lower Sedentary Time are Associated With Less Insulin Resistance and Favorable Adipokine Profile: The Framingham Study

Abstract

Background: Physical activity (PA) and sedentary time (ST) are associated with metabolic diseases. More PA and less ST may also be associated with a more favorable adipokine profile and greater insulin sensitivity, even in the absence of weight loss. We tested this hypothesis by relating a comprehensive panel of adipokines in relation to accelerometry-determined PA measures in a community-based cohort. Methods: We assessed PA and ST using Actical accelerometers in 2109 participants from Framingham Heart Study Generation 3 and Omni 2 cohorts (mean age 40 y, 54% F) free of diabetes. Circulating adipokines, C-reactive protein (CRP), insulin-like growth factor (IGF)-1 and insulin resistance (HOMA-IR) were dependent variables, and steps/day, moderate to vigorous PA (MVPA), and ST/weartime were independent variables in multivariable regression analyses. We adjusted for cohort, age, sex, season of exam, overnight wear, residence (New England or other), body mass index (BMI), cardiovascular disease, hypertension, and smoking. Models for PA were also adjusted for ST, and models for ST also adjusted for MVPA. Results: Overall, 49% of participants met the PA Guidelines (>150 min/wk MVPA). Higher MVPA and more steps per day were associated with lower insulin resistance and CRP levels. More steps were also associated with lower leptin and higher IGF-1 levels. ST was positively associated with insulin resistance (p<0.001), but this relation was not significant after adjusting for MVPA. ST was associated with higher leptin, adipocyte fatty acid-binding protein (FABP)4 and retinol binding protein (RBP)4 levels. Conclusions: Our cross-sectional study of a community-based sample demonstrated associations of PA and ST with metabolic factors and several adipokines, after adjusting for BMI. These findings may provide clues linking PA to cardiometabolic risk by influencing insulin resistance and inflammation, compared to ST potentially modulating fatty acid binding proteins.