Abstract 18867: High Density Electrical Mapping With Conformal Electrode Arrays

Abstract

Introduction: High-resolution mapping catheters could facilitate detailed mapping of complex arrhythmias, such as persistent atrial fibrillation (AF). Detailed map information acquired with a high-resolution catheter could potentially improve the efficacy of ablation. The goal of this study was to test the feasibility of cardiac mapping using a catheter-based conformal high-density (HD) electrode array (16 electrodes/cm2) that significantly enhances spatial mapping resolution relative to existing devices. Methods: In vivo studies of the catheter-based HD electrode arrays were performed in 4 swine. The HD array was embedded in the balloon and was used to measure atrial electrical activity during both sinus rhythm (SR) and pacing-induced AF. Signal fidelity was evaluated during maneuvers of the catheter in the atria. Results: Activation patterns were identified and propagation speeds were characterized during sinus rhythm and pacing-induced AF. These HD recordings were then used to generate iso-potential conduction maps (Figure). Conclusions: Electrogram measurement with the HD conformal electrode array was feasible, and enabled fine spatio-temporal mapping of the atria during SR and AF, and has the potential to help better define the arrhythmogenic substrate(s) of complex arrhythmias.