Abstract 1876: Assessment of exposure to potential lung carcinogens in Xuanwei and Fuyuan, China: Particulate exposure from cooking and heating stoves

Abstract

Abstract Residents in Xuanwei, China have the highest lung cancer incidence rates in China for both men and women, despite the fact that almost all women are non-smokers. Several lines of research have provided strong support that the excess lung cancer rate in this region is caused primarily by emissions from smoky coal exposure. We have carried out a hospital-based case-control study of non-smoking female lung cancer in Xuanwei and its neighboring county, Fuyuan, to identify which constituents of coal combustion emissions and other indoor environmental exposures are causing the high lung cancer rates in this region. In order to develop individual estimates of exposure to known or suspected lung carcinogens, we designed a comprehensive exposure assessment study of 163 households in this region to evaluate exposure to PAHs, PM2.5, silica, and other exposures from coal and wood burning. Homes that used three main fuel types (i.e., smoky coal, smokeless coal and wood), and eight stove types [e.g., firepit, fixed or portable stove, with or without ventilation] were identified and households were sampled on two consecutive days. Up to 30 households were selected for each combination of fuel and stove type. A subgroup of 53 households was measured at two time-points during the study year (e.g. summer and winter). The female head of each household was asked to wear a 24-hour personal PM2.5 air sampler at the same time that 24-hour area air sampling was employed in the main living area. Personal and area particulate matter samples (PM2.5) were collected in each home. These samples were also used to quantify particle bound PAHs including BaP (by GC/MS), elemental components (by XRF and ICP/MS), and silica (by XRD). XAD2 samples were collected for the quantification of gaseous PAHs. Other samples, including radon and organic vapor, fuel and ash were also obtained. We also collected information on potential factors that could influence exposure, such as house characteristics, stove type, fuel type and use, amount of fuel used, amount of time spent in each room. Initial analyses show that people using wood burned in firepits were exposed to the highest levels of PM2.5 measured in area (536.3±370.5 µg/m3) and personal samples(419.8±283.3 µg/m3). Burning smokeless coal in a high stove with a chimney was associated with the lowest exposure to PM2.5 (62.2±34.1 µg/m3, 62.5±29.9 µg/m3 for area and personal samples, respectively). These data show that there is a wide range of exposure to PM2.5 in this population. These data and other exposure information from this study will be used in the future to model environmental exposures and risk of lung cancer in this special, high risk population. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1876. doi:10.1158/1538-7445.AM2011-1876