Abstract 18728: Plasma Heparin Cofactor II Activity is a Predictor of Diffuse Coronary Artery Narrowing in Patients with Diabetes Mellitus

Abstract

Background: Heparin cofactor II (HCII) is a major physiological inhibitor of thrombin action. We previously reported high plasma HCII was protective against in-stent restenosis after coronary stenting and carotid atherosclerosis. Furthermore, we reported that HCII was a predictor of cardiovascular events in patients with coronary heart disease. Kataoka et al reported patients with DM had smaller coronary vessel and longer diseased segment than those with impaired glucose tolerance (IGT) and normal glucose tolerance. HCII and morphologic characteristics of diabetic coronary was unknown. Methods: We enrolled 20 diabetic patients examined by coronary angiography, sequentially (13 males and 7 females; age, 67.9+/-10.4yrs, HbA1c>/=7.0%). Coronary cinearteriography was analyzed by quantitative coronary angiography (QCA) with Cardiovascular Measurement System (CCIP-310/W). Segment diameter<1.5mm as diseased lesions were determined. And diseased lesion length and HCII activity were analyzed, statistically. Results: The mean plasma level of HCII activities was 101.4+/-18.6%. And the mean of diseased lesion length was 13.7+/-12.0mm. Multivariate analysis showed age, low-HDLemia, smoking habit and disease period of DM were positively correlated with ALL, and HCII activity was negatively correlated. Univariate analysis showed HCII activity was negatively correlated with ALL, and disease period of DM was positively. That is, HCII activity and disease period of DM were correlated with lesion length of coronary artery diffuse-narrowing in diabetic patients. . Conclusions: The results suggested that low level of plasma HCII activity was correlated with diffuse coronary artery narrowing in patients with diabetic mellitus.