Abstract 18720: Association of Triglyceride-Glucose Index and Risk of Coronary Heart Disease, Congestive Heart Failure, Stroke and Hypertension Among Non-Diabetic Patients: NHANES Study 2001-2020

Abstract

Introduction: Not enough studies addressed the predictive value of the triglyceride glucose (TYG) index for developing cardiovascular diseases. This study highlights the association between TYG index and the risk of cardiovascular disease among non-diabetic patients. Methods: Our study used the National Health and Nutrition Examination Survey (NHANES) data. Data from 2001 to 2020 was involved, and the analysis was performed using a 4-year fasting weight (WTSAF4YR) per NHANES analysis criteria. We included non-diabetic participants aged 18 years or older. The Statistical Package for the Social Sciences (SPSS) v. 28 was used for the analysis. The sensitivity and specificity of the TyG index in predicting the endpoints of interest (coronary heart disease (CHD), Congestive Heart Failure (CHF), Heart attack (HA), Stroke, and Hypertension (HTN)) were calculated by receiver operating characteristic (ROC) analysis. We performed univariate and multivariate logistic regression to analyze the associated factors with the endpoints of our study. Results: Our study involved 10,937 non-diabetic individuals. The age was 48±18 years. Individuals with a TyG index of>8.96 had higher BMI, waist circumference, systolic/diastolic blood pressure, total cholesterol, LDL, and Apo-B levels (p<0.001). Overall, 360, 359, 385, 237, and 3254 patients had CHD, stroke, HA, CHF and HTN, respectively. We evaluated the predictor values of TyG index for CHF (AUC: 54.75%, 95% CI:0.542-0.614), stroke (AUC:52.32%,95%CI:0.529)-0.584), HA (AUC:55.67%, 95%CI:0.595-0.646), HTN (AUC: 55.59%, 95%CI:0.574-0.597), CHD (AUC: 50.31%,95%CI:0.592-0.646), and all of them were statistically significant(p-value<0.05). Conclusions: The value of the TyG index was a poor indicator for the studied cardiovascular diseases (congestive heart failure, stroke, heart attack, high blood pressure, and coronary heart disease).