Abstract 18411: The Causal Association Between Coronary Artery Disease and Atrial Fibrillation in East Asian Ancestry

Abstract

Background: Previous studies have reported a causal association between coronary artery disease (CAD) and atrial fibrillation (AF) in the European populations. However, it is unclear whether the causal association the exists in East Asian populations. Methods: We assessed the causal relationship between CAD and AF using 2-sample Mendelian randomization (MR) in the East Asian populations. Additionally, we performed multivariable MR, correcting obesity, smoking initiation, alcohol intake frequency, and hypertension to further explore the causality between CAD and AF. Results: The calculated odds ratios (ORs) and 95% confidence intervals (CIs) for CAD using inverse-variance weighted, MR-Egger, and weighted-median analysis were 0.984 (0.955-1.014; P = 0.285), 0.957 (0.899-1.019; P = 0.191), and 0.974 (0.945-1.004; P = 0.088), respectively; for AF, the results were 1.066 (0.944-1.203; P = 0.302), 0.790 (0.546-1.142; P = 0.216), and 1.258 (1.098-1.441; P < 0.001). After adjusting common risk factors, the genetically predicted CAD was also causally associated with an 18.5% increased risk of AF (OR = 1.185; 95% CI = 1.065-1.319; P = 0.002), but no causal effect of AF on the risk of CAD. Conclusions: Our findings suggest that genetically predicted CAD is causally associated with an increased risk of AF in East Asian populations.