Abstract 183: Prognosis of Intracranial Arterial Dolichoectasia in Patients With Ischemic Cerebrovascular Disease

Abstract

Objectives: Intracranial arterial dolichoectasia (IADE) refers to the vascular abnormities of elongation, tortuous, and dilating of the brain vessels. The incidence of IADE in patients with ischemic cerebrovascular disease was higher, however, the prognosis of IADE in patients with ischemic cerebrovascular diseases was still not clear. The purpose of this study was to explore the association between the IADE and the clinical prognosis of patients with ischemic cerebrovascular disease in China. Methods: Patients with acute ischemic stroke and transient ischemic attack were enrolled in a prospective, multicenter cohort study. Baseline clinical information and follow-up information were collected. The imaging information of the patients (baseline magnetic resonance imaging) was collected, and IADE patients were selected through the centralized double-blinded interpretation. The endpoints included stroke recurrence, composite events, and all-cause mortality at 12 months. The multivariate Cox regression model was used to explore the association between IADE and the clinical prognosis of ischemic cerebrovascular disease. Results: 8219 patients with ischemic cerebrovascular disease were enrolled in this study, 395 patients of whom had IADE. Patients with IADE had a lower stroke recurrence rate (4.8% vs 7.8%, P=0.03) and lower composite events rate (5.3% vs 8.1%, P=0.04) at 12 months. The elongation of the basilar artery was also associated with stroke recurrence (6.8% vs 8.4%, P=0.009) and composite events rate (7.1% vs. 8.7%, P=0.009) at 12 months. After multivariate Cox regression, IADE was still independently associated with decreased stroke recurrence (HR 0.59, 95% CI 0.36-0.95,P=0.03) and composite events (HR 0.63, 95% CI 0.40-0.99,P=0.05) at 12 months . The elongation of the basilar artery was still independently associated with decreased stroke recurrence (HR 0.80, 95% CI 0.67-0.95, P=0.01) and composite events (HR 0.81, 95% CI 0.68-0.95, P=0.01) at 12 months. Conclusion: IADE and the elongation of the basilar artery were both independently associated with decreased stroke recurrence and composite events at 12 months.