Abstract 18033: Nationwide Trends in Major Adverse Cardiac and Cerebrovascular Events Hospitalizations and Cardiac Arrests in Young Women (18-44 Years), 2016-2019

Abstract

Introduction: Incidence of Major Adverse Cardiac and Cerebrovascular Events (MACCE) and cardiac arrests are increasing in younger women aged 18 - 44 years in the context of increasing metabolic syndrome and nontraditional risk factors such as stress, anxiety, and depression. We aim to assess recent trends in hospitalizations associated with MACCE and cardiac arrest in them. Methods: National Inpatient Sample database from 2016 - 2019 was used to examine temporal trends, risk factors, disparities, and outcomes related to hospitalization for MACCE and cardiac arrest in young women (18-44 years). We used the Chi-square test to evaluate the differences and multivariate logistic regression analysis for outcome analysis. Results: A total of 24,882,601 young women admissions were identified, in which 0.8% had MACCE and 0.1% had cardiac arrest. Between 2016 - 2019, there is a statistically significant increase in MACCE (0.7 % to 0.9 %) and cardiac arrests (0.1% to 0.2 %), p<0.001. African Americans experienced higher adjusted odds of MACCE compared to whites (OR 1.06, 95% CI: 1.02-1.09, p<0.001). Asian, white, and Hispanics experienced the lowest (0.1%) increase, while Native Americans experienced the highest (0.6%) increase in MACCE. There is a decrease in adjusted odds in Hispanics and Asians compared to whites in both MACCE and Cardiac arrest with statistical significance. Hypertension was African Americans’ most prevalent risk factor (62%). Length of stay was the same in all races (4 days) except in whites (3 days), with p value < 0.001. The total cost of hospitalization was highest in Hispanics (95067USD) and least in blacks (75074USD). Conclusion: The rise in MACCE and cardiac arrest cases among young women highlights the need to expand the literature on the causes of these trends, female specific risk factors and racial disparities. The declining cardiovascular health of this population demands targeted prevention, early treatment and management strategies.