Abstract # 1792 Peripheral inflammatory mediators and p11 levels in peripheral blood mononuclear cells from patients with Parkinson’s disease

Abstract

Mood and cognitive impairment associated with Parkinson’s disease (PD) represents a healthcare problem, with between 50 and 70% of PD patients suffering from depression. Inflammation plays a role in both PD and depression, with some patients showing an increase in pro-inflammatory mediators both centrally and peripherally. It has been suggested that the initial inflammation associated with PD may occur prior to the onset of the disease, thus biomarkers to identify the prodromal stages of PD may prove beneficial for earlier treatment. This project assessed p11 expression in peripheral blood mononuclear cells (PBMCs) in PD patients with and without depression, as well as investigating their peripheral inflammatory profile. Blood samples were obtained from 20 PD patients, 20 PD patients with depression (PDD) and 16 age and gender matched healthy controls (HC). PBMC composition and p11 levels in monocyte and T cell subsets, and NK cells were assessed using multicolor flow cytometry. Inflammatory mediators were measured using the 30-plex MSD assay. There were no significant differences in PBMC composition or inflammatory mediator levels between the groups. Monocytes from PDD patients expressed higher levels of p11 as compared to HCs ( p p