Abstract 17829: Frequency-domain Optical Coherence Tomography Findings of Population With High Skin Auto Fluorescence

Abstract

Objective: We aim to assess the coronary artery plaque features in patients with high skin auto fluorescence (SAF) using frequency-domain optical coherence tomography (FD-OCT). Background: SAF, a non-invasive measurement of the accumulation for glycation end products (AGEs) level of skin, has been reported as a useful marker for micro/macro vascular complications. Moreover patients involved with coronary artery disease (CAD) with higher SAF show worse clinical outcome compared to patients with lower SAF. Due to its unprecedented high resolution (~10μm axial), optical coherence tomography (OCT) has been increasingly used for plaque assessments. In this situation, there is no data evaluating the OCT findings of high SAF population. Methods: We prospectively enrolled 108 consecutive patients with de novo coronary artery disease underwent percutaneous coronary intervention (PCI) with FD-OCT images at pre-PCI. SAF was measured before PCI procedure. We divided the population into two group high SAF group (greater than or equal to 2.6) and low SAF group (less than 2.6), then compared FD-OCT findings between high and low SAF group. Furthermore we evaluated the predictor of thin cap fibroatheroma (TCFA) and plaque rapture by FD-OCT. Results: High SAF group shows much more TCFA and plaque rapture compared to low SAF group (63.9% vs 31.9%, p<0.001 and 32.8% vs 12.8%, p<0.001, respectively). In multivariable analysis, age (odds ratio [OR]: 0.96; 95% confidence interval [CI]: 0.92 to 1.00; p = 0.046) and SAF (<2.6 as reference) (odds ratio [OR]: 5.89; 95% confidence interval [CI]: 2.39 to 14.51; p < 0.001) were considered to be the predictor of TCFA and SAF (odds ratio [OR]: 4.23; 95% confidence interval [CI]: 1.23 to 14.51; p = 0.022), gender (male as reference) (odds ratio [OR]: 0.12; 95% confidence interval [CI]: 0.03 to 0.56; p = 0.007) and LDL (odds ratio [OR]: 1.2; 95% confidence interval [CI]: 1.02 to 1.42; p = 0.029) were considered to be the predictor of plaque rapture. Conclusion: Based on FD-OCT imaging, high SAF group shows the association with TCFA and plaque rapture compared to low SAF group. These OCT findings may explain the worse clinical outcomes of high SAF patients.