Abstract 17788: Long-Term Impact of Previous Severe Preeclampsia on Heart and Large Artery Structure and Function

Abstract

Introduction: Women with previous history of preeclampsia (PE) are at risk of cardiovascular events. Hypothesis: To evaluate subclinical cardiovascular repercussions by noninvasive methods in women with previous severe PE. Methods: Cross-sectional study was carried out in a tertiary hospital. Women evaluated 2 to 5 years after delivery and divided into 3 groups: isolated preeclampsia (IPE=30), superimposed preeclampsia and/or chronic hypertension (Sup/HC)=60 and normal gestation (NG) =30. Variables analyzed: age, body mass index (BMI), systolic blood pressure (SBP) and diastolic BP (DBP) by ambulatory blood pressure monitoring (ABPM-24h) and office, central pressure (BPc) by Sphigmocor®; pulse wave velocity-PWV by Complior® e echocardiogram (ViviDI-GE®). Results: Clinical : Age (years): (Sup/HC=38 vs NG=34,6 vs IPE= 31, p <0,001). BMI (kg/m2): Sup/HC=32,6 vs NG=27,1 vs IPE=28,4, p< 0,001); SBP (mmHg): ABPM-24h (awake): (Sup/HC=128,4 vs NG=117,5, p<0,004); office: (IPE=124,8, Sup/HC=133,6 vs NG=114,6, p <0,001). DBP (mmHg) : office (IPE=80,4;Sup/HC=87,8 vs NG= 73,3) and (Sup/HC=87,8 vs IPEH= 80,4), (p<0,001); SBPc (IPE=115,4, Sup/HC=124,4 vs NG 105,8, p < 0,001). DBPc: (Sup/HC=88,8 vs NG= 75; Sup/HC=88,8 vs IPEH=81,8, p<0,001); Vascular : PWV (m/s) (Sup/HC=8,1 vs NG=6,8, IPE=7,0, p<0,012); Echocardiogram : Septum wall thickness (mm) (IPE=9,2 vs Sup/HC=9,7, NG=8,4, p<0,004); left atrium (mm) (Sup/HC=38 vs IPE=36 vs 34, p<0,005); left ventricle mass index (g/m2) (Sup/HC=81 vs IPE=80 vs. NG=66, p<0,002), Conclusions: Women with previous IPE had elevated BP values and cardiac repercussions compared to previous normal gestation while previous superimposed or chronic hypertension had also elevated BP, vascular and cardiac impairment compared to other previous gestational conditions.