Abstract 177: Hemodynamic Status From Photoplethysmography, Signs of Successful Pregnancy

Abstract

The key physiological condition for successful pregnancy is a critical issue in reproductive science. Many studies have shown that the pregnancy process requires a lot of subtle cardiovascular adaptation, including a decrease in systemic vascular resistance, an increase in maternal heart rate, stroke volume, and cardiac output. Those adaptation will also lead to changes in the arterial pulse spectrum. Since pregnancy requires the mother's competency to change the hemodynamic state, an interesting question is if the pre-pregnancy hemodynamics of the cardiovascular system affect the clinical pregnancy rate of each embryo transfer. Therefore, we initiated an observational study to validate our conjecture. We recruited 116 women of childbearing age(range 22 to 41 years) who planned to carry out in vitro fertilization(IVF). Each subject underwent photoplethysmography(PPG) before embryo implantation. We calculated the first ten harmonic amplitudes (C1~C10) and phases (P1~P10) from the pulse data of PPG using the Fourier transform method, and tracked these women to 42 days after implantation to confirm the successful pregnancy. The results showed that the subjects with successful IVF had higher C4 and C7(P=0.006; P=0.018), compared with those who failed the IVF. We then classified the enrolled patients into quartile groups of C4 and C7 respectively. Log rank test further proved that the cumulative rates of successful pregnancy were significant higher for those with the higher C4 and C7, taking groups with smaller values as reference(Figure 1). In conclusion, maternal hemodynamic state before implantation have an impact on the successful pregnancy rate during IVF.