Abstract 17367: Impact of Cardiac MRI on Myocarditis Management and Patient Outcomes: A Big Data Study

Abstract

Introduction: The lack of consensus regarding the role of cardiac magnetic resonance (CMR), an essential myocarditis imaging modality, leads to patient care inconsistencies. We investigated the impact of CMR on resource utilization and patient outcomes in myocarditis patients. Methods: Using TriNetX, we conducted a large, retrospective analysis between 1/01/2010 and 6/02/2023. We compared myocarditis patients with and without CMR within 3 months of diagnosis. Matching cohorts (n=7,488 per cohort) were created based on demographic variables and comorbidities including lipidemias, hypertension, diabetes, sarcoidosis, and select heart diseases within 1 month of diagnosis. The analysis yielded risks to compare outcomes, resource utilization, and medication and procedure usage. Results: Patients without CMR had higher mortality rates compared to those who received CMR in the context of higher mortality between 2017-2022 compared to 2010-2016 (Risk 2.728% vs 2.314%, p<0.05). Mortality risk was higher in the non-CMR cohort at 3 months, 1 year and 5 years. Risks of developing cardiomyopathy and heart failure were higher in the non-CMR group. Between 1 and 5 years, the CMR group experienced fewer hospitalizations (Risk 11.6% vs 14.9%, p<0.05). CMR recipients had a higher chance of receiving all GDMT categories within 30 days, and most GDMT categories within 1 year. Conclusions: Myocarditis patients referred for CMR experienced lower hospitalization and mortality rates over 5 years, and were less likely to develop complications and more likely to receive early GDMT. These findings imply potential downstream impacts of CMR on optimal therapeutic management and risk reduction.