Abstract 16924: Diagnostic Accuracy of Quantification Myocardial Perfusion Ratio Derived From Dynamic CT Perfusion Imaging for Detection of Functionally Significant Stenosis

Abstract

Introduction: Quantification perfusion ratio (QPR) is defined as the ratio between myocardial blood flow (MBF) in the stenosis-related territory and MBF in the non-stenosis-related territory derived from stress dynamic CT myocardial perfusion (CTP) imaging. Hypothesis: We sought to evaluate whether QPR can be used as a novel non-invasive method for detection of functionally significant coronary artery stenosis compared with fractional flow reserve (FFR). Methods: This study was retrospectively included 25 consecutive patients (32 vessels) with coronary artery disease and examined with CT angiography, CTP, coronary angiography, and FFR. QPR and stress MBF results were compared with invasive FFR using a threshold of 0.80. Results: The QPRvalues were significantly correlated to FFR values (R=0.865,P <0.0001, Fig 1). The area under the receiver operator curve was larger for QPR (0.937) compared with stress MBF (0.812, Fig 2). The diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of QPR were 93.8%, 86.7%, 100%, 100%, and 89.5%, respectively. Conclusions: QPR was feasible and provided high diagnostic value for detecting abnormal FFR in patients with stable coronary artery disease.